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・NTRK1 Split Dual Color FISH Probe(SP025)
Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient
Oncotarget : 2017 Aug 15; 8(33): 55353–55360.


・CCND2 Split Dual Color FISH Probe(SP033) 
Pleomorphic mantle cell lymphoma morphologically mimicking diffuse large B cell lymphoma: common cyclin D1 negativity and a simple immunohistochemical algorithm to avoid the diagnostic pitfall
Histopathology. 2017 May;70(6):986-999. doi: 10.1111/his.13161. Epub 2017 Mar 10.

・MDM2/CEN12p Dual Color FISH Probe(GC020)
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma
Pathology - Research and Practice : Volume 213, Issue 6, June 2017, Pages 634-638 (jp)

・MYB Split Dual Color FISH Probe(SP016)
Human papillomavirus-related carcinoma with adenoid cystic-like features: a series of five cases expanding the pathological spectrum, Histopathology. 2017 Jun 30. doi: 10.1111/his.13301. [Epub ahead of print]

・FGF19/CEN11p Dual Color FISH Probe(GC104)
FGF19 genetic amplification as a potential therapeutic target in lung squamous cell carcinomas
Thorac Cancer. 2017 Sep 14. doi: 10.1111/1759-7714.12504. [Epub ahead of print]

・BRCA1/CEN17q Dual Color FISH Probe(GC073)
Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers
Cancer Letters : Volume 397, 1 July 2017, Pages 127-132

・ACTN4/CEN19p Dual Color FISH Probe(GC022) 
Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer
International Journal of Oral and Maxillofacial Surgery : Volume 46, Issue 8, August 2017, Pages 968-976 (jp)

・FGFR1/CEN8q Dual Color FISH Probe(GC055)
An mRNA Gene Expression–Based Signature to Identify FGFR1-Amplified Estrogen Receptor–Positive Breast Tumors
The Journal of Molecular Diagnostics : Volume 19, Issue 1, January 2017, Pages 147-161

・PIK3CA/CEN3q Dual Color FISH Probe(GC077)
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer, Sci Rep. 2017; 7: 10240.

・VHL/CEN3q Dual Color FISH Probe(GC032)
Sarcomatoid renal cell carcinoma has a distinct molecular pathogenesis, driver mutation profile and transcriptional landscape
Clinical Cancer Research : Published OnlineFirst July 14, 2017

・c-met/CEN7q(GC004), SMO/CEN7q(GC134) Dual color FISH Probe
Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR, Oncotarget. 2017 Apr 4; 8(14): 23020–23032.

・MDM2/CEN12p Dual Color FISH Probe(GC020)
Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status
Human Pathology : Volume 63, May 2017, Pages 63-69 (jp)

・KIAA1549/BRAF1, DY Dual Color FISH Probe(TR015)
Comprehensive genetic characterization of rosette-forming glioneuronal tumors: independent component analysis by tissue microdissection, Brain Pathol. 2016 Nov 28. doi: 10.1111/bpa.12468. [Epub ahead of print]

・DDR2/CEN1p(GC176), NTRK1/CEN1p(GC175) Dual Color FISH Probe 
Frequent amplification of receptor tyrosine kinase genes in well-differentiated/ dedifferentiated liposarcoma
Oncotarget. 2017 Feb 21; 8(8): 12941–12952. (jp)

(72)FGF9/CEN13q Dual Color FISH Probe(GC147)
Significance of FGF9 gene in resistance to anti-EGFR therapies targeting colorectal cancer: A subset of colorectal cancer patients with FGF9 upregulation may be resistant to anti-EGFR therapies
Mol Carcinog. 2017 Jan;56(1):106-117. doi: 10.1002/mc.22476. Epub 2016 Feb 24.

・CIC Split Dual Color FISH Probe(SP035)
Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes, Virchows Arch. 2017 Apr;470(4):373-380. doi: 10.1007/s00428-017-2072-8. Epub 2017 Feb 14.

・FGFR1 Split Dual Color FISH Probe(SP026)
Histopathological and Genetic Review of Phosphaturic Mesenchymal Tumours, Mixed Connective Tissue Variant
Histopathology. 2017 Aug 31. doi: 10.1111/his.13377. [Epub ahead of print]

・CREB1 Split Dual Color FISH Probe(SP059)
Angiomatoid fibrous histiocytoma: a series of seven cases including genetically confirmed aggressive cases and a literature review
BMC Musculoskeletal Disorders : 2017 18:31, (jp)

・MDM2/CEN12p(GC020), USP6 split(SP029) Dual Color FISH Probe 
HIF-1α, MDM2, CDK4, and p16 expression in ischemic fasciitis, focusing on its ischemic condition
Virchows Archiv : July 2017, Volume 471, Issue 1, pp 117–122 (jp)

・FGFR1/ETO/CCNE2 TriColor FISH Probe
Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency PLOS GENETICS : June 21, 2017 (jp)

・CD274(PD-L1)/CEN9q Dual Color FISH Probe(GC141)
Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1+ immune cells in Epstein–Barr virus-associated gastric cancer: the prognostic implications
Mod Pathol. 2016 Dec 9. doi: 10.1038/modpathol.2016.202. [Epub ahead of print]

・MYB Split Dual Color FISH Probe(SP016)
Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells
The Journal of Pathology : Volume 39, Issue 2, June 2016, pages 197 – 205

・KRAS/CEN12q Dual Color FISH Probe(GC017)
Clonal evolution and KRAS-MET coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer, EMSO Open ( Cancer Horizons ) : 2016 1

・CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma, MODERN PATHOLOGY : 2016, 00, 1-8

・PLAG1/CEN8p Dual Color FISH Probe (GC114)
Prognostic factors in the myoepithelial-like spindle cell type of metaplastic breast cancer
Virchows Archiv : August 2016, Volume 469, Issue 2, pp 191–201

・NF2/CEN22q Dual Color FISH Probe(GC003)
Intraoral Pseudo-Onion Bulb Intraneural Proliferations in a Patient with Hemimandibular Hyperplasia: A Case Report and Review of the Literature, Head Neck Pathol. 2016 Dec;10(4):475-480. Epub 2016 May 2.

・ROS1 Split Dual Color FISH Probe(SP015)
Expression levels of ROS1/ALK/c-MET and therapeutic efficacy of cetuximab plus chemotherapy in advanced biliary tract cancer
Sci Rep. 2016; 6: 25369.

・BAP1/CEN3q Dual Color FISH Probe(GC097)
BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as a Diagnostic Tool in Malignant Pleural Mesothelioma Classification: A Large Retrospective Study
J Thorac Oncol. 2016 Nov;11(11):2006-2017. doi: 10.1016/j.jtho.2016.06.020. Epub 2016 Jul 13.

・FGFR2/CEN10p Dual Color FISH Probe (GC018)
Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study
Cancer Research : Published OnlineFirst June 16, 2016

・BRAF/CEN7q(GC115), EGFR/CEN7q(GC005), KRAS/CEN12q(GC017) Dual Color FISH Probe 
Molecular landscape of acquired resistance to targeted therapy combinations in BRAF mutant colorectal cancer
Cancer Research : Published OnlineFirst June 16, 2016

・NTRK1 Split Dual Color FISH Probe(SP025)
NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer
Oncotarget. 2016 Feb 16; 7(7): 8399–8412.

・NF2/CEN22q(GC003), BAP1/CEN3q(GC097)  and  p16/CEN9q(GC002) Dual Color FISH Probe 
The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma
Modern Pathology; Augusta29.1 (Jan 2016): 14-24.

・EGFR/CEN7q Dual Color FISH Probe(GC005)
Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer
Nature Communications 7 : Article number: 13665 (2016)

・NF2/CEN22q Dual Color FISH Probe(GC003)
Clinical impact of targeted amplicon sequencing for meningioma as a practical clinical-sequencing system 
Modern pathology 2017 Jul: 29(7) : 708-716 


・FGFR2 Split Dual Color FISH Probe
Distinct Clinicopathologic and Genetic Features of 2 Histologic Subtypes of Intrahepatic Cholangiocarcinoma The American Journal of Surgical Pathology, Volume 40, Number 8, 2016 (jp)

・TFE3 split Dual Color FISH Probe(SP004)
Xp11.2/TFE3 translocation-associated renal cell carcinoma with multilocular cystic structures in an elderly patient: a case report
Int J Clin Exp Pathol 2016;9(3):3987-3992 (jp)

・FGFR1 split Dual Color FISH Probe(GC055)
FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib
Cancer Science : November 2016, Volume 107, Issue 11, Pages 1667-1676 (jp)

・ROS1 split Dual Color FISH Probe(SP015)
Pulmonary Neplasms in Patients with Birt-Hogg-Dube Syndrome: Histopathological Features and Genetic and Somatic Events
PLoS One. 2016 Mar 14;11(3):e0151476. doi: 10.1371/journal.pone.0151476. eCollection 2016.

・CEN13q/18q/21q FISH Probe(CM3002)、CEN21q/Xp/Yq FISH Probe(CM3003)
J Obstet Gynaecol Res. 2016 May 2. doi: 10.1111/jog.12982. [Epub ahead of print]
Practicability of prenatal testing using lectin-based enrichment of fetal erythroblasts.

・CEN17q FISH Probe(C017q)
Hum Pathol. 2016 Jun;52:74-82. doi: 10.1016/j.humpath.2016.01.004. Epub 2016 Feb 4.
Fluorescent and chromogenic in situ hybridization of CEN17q as a potent useful diagnostic marker for Birt-Hogg-Dubé syndrome-associated chromophobe renal cell carcinomas.

・Subtelomere FISH Probe、CEN FISH Probe
J Hum Genet. 2016 May 19. doi: 10.1038/jhg.2016.39. [Epub ahead of print]
Reproductive outcomes following preimplantation genetic diagnosis using fluorescence in situ hybridization for 52 translocation carrier couples with a history of recurrent pregnancy loss

・FGF9/CEN13q Dual Color FISH Probe(GC147)
Mol Carcinog. 2016 Feb 24. doi: 10.1002/mc.22476. [Epub ahead of print]
Significance of FGF9 gene in resistance to anti-EGFR therapies targeting colorectal cancer: A subset of colorectal cancer patients with FGF9 upregulation may be resistant to anti-EGFR therapies.

・NCOA2 Split Dual Color FISH Probe(SP013)
Histopathology. 2016 Feb 4. doi: 10.1111/his.12943. [Epub ahead of print]
Histological Spectrum of Angiofibroma of Soft Tissue: Histological and genetic analysis of 13 cases.

・IGH/SOX5, DY Translocation Dual Color FISH Probe(TR012)

Int J Hematol. 2015 Jun 27. [Epub ahead of print]

Identification of the SOX5 gene as a novel IGH-involved translocation partner in BCL2-negative follicular lymphoma with t(12;14)(p12.2;q32).

・Chromosome Res. 2015 May 8. [Epub ahead of print]

Multicolor FISHs for simultaneous detection of genes and DNA segments on human chromosomes.

・CAMTA1 Split Dual Color FISH Probe(SP032)

Histopathology. 2015 Apr 16. doi: 10.1111/his.12713. [Epub ahead of print]

CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma.

・BRAF1/CEN7q Dual Color FISH Probe(GC115)

Oncol Lett. 2015 Feb;9(2):709-712. Epub 2014 Nov 20.

Increased BRAF copy number in lung adenocarcinoma.


・FGFR3 Split Dual Color FISH Probe(SP011)

Mol Cancer Ther. 2015 Mar;14(3):704-12. doi: 10.1158/1535-7163.MCT-14-0927-T. Epub 2015 Jan 14.

Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1.


・CDK4/CEN12q Dual Color FISH Probe(GC038)、

MDM2/CEN12p Dual Color FISH Probe(GC020)

Pathol Res Pract. 2015 Feb;211(2):117-24. doi: 10.1016/j.prp.2014.12.002. Epub 2014 Dec 11.

Malignant solitary fibrous tumor with high-grade nuclear atypia: an alternate entity for the undetermined tumor group.


・c-met/CEN7q Dual Color FISH Probe (GC004)

BMC Cancer. 2015 Feb 6;15:31. doi: 10.1186/s12885-015-1019-1.

MET FISH-positive status predicts short progression-free survival and overall survival after gefitinib treatment in lung adenocarcinoma with EGFR mutation.


・FGFR2/CEN10p Dual Color FISH Probe(GC018)

Cancer Sci. 2014 Jun 28. doi: 10.1111/cas.12470.

Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic



・RET Split Dual Color FISH Probe (SP018)

Mol Cancer Ther. 2014 Dec;13(12):2910-8. doi: 10.1158/1535-7163.MCT-14-0274. Epub 2014 Oct 27.

Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.


・EML4/ALK, DY Translocation Dual Color FISH Probe (TR001) 

J Thorac Oncol. 2014 Nov;9(11):1638-46. doi: 10.1097/JTO.0000000000000311.

A novel mechanism of EML4-ALK rearrangement mediated by chromothripsis in a patient-derived cell line.


・FGFR2/CEN10p Dual Color FISH Probe(GC018)

Ann Surg Oncol. 2014 May;21(5):1561-8. doi: 10.1245/s10434-013-3456-x. Epub 2014 Jan 3.

Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets.


・NCOA2 Split Dual Color FISH Probe(SP013)

Pathol Int. 2014 May;64(5):237-42. doi: 10.1111/pin.12163.

Angiofibroma of soft tissue with fibrohistiocytic features and intratumor genetic heterogeneity of NCOA2 gene rearrangement revealed by chromogenic in situ hybridization: a case report.


・c-met/CEN7q Dual Color FISH Probe(GC004) 

Oncotarget. 2014 Apr 30;5(8):2293-304.

Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study.


・ECT2/CEN3q Dual Color FISH Probe(GC096)

Cancer Sci. 2014 Apr;105(4):490-7. doi: 10.1111/cas.12363. Epub 2014 Mar 19.

ECT2 amplification and overexpression as a new prognostic biomarker for early-stage lung adenocarcinoma.


・c-met/CEN7q Dual Color FISH Probe(GC004) 

Onco Targets Ther. 2014 Apr 3;7:513-24. doi: 10.2147/OTT.S60122. eCollection 2014.

Primary concomitant EGFR T790M mutation predicted worse prognosis in non-small cell lung cancer patients.


・RET Split Dual Color FISH Probe(V.2) (SP019)

Mol Cancer Ther. 2014 Dec;13(12):2910-8. doi: 10.1158/1535-7163.MCT-14-0274. Epub 2014 Oct 27.

Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.


・CCNE1/CEN19p Dual Color FISH Probe(GC013)

Mod Pathol. 2013 Dec 6. doi: 10.1038/modpathol.2013.209.

Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma. 


・AKT3/CEN1q Dual Color FISH Probe(GC071)

Histopathology. 2013 Oct 19. doi: 10.1111/his.12313.

Investigation of molecular alterations of AKT-3 in triple-negative breast cancer.


・ACTN4/CEN19p Dual Color FISH Probe(GC022)

Ann Oncol. 2013 Oct;24(10):2594-600. doi: 10.1093/annonc/mdt293. Epub 2013 Jul 30.

Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification.


・CEN11q FISH Probe

Pathol Int. 2013 Sep;63(9):469-75. doi: 10.1111/pin.12088. Epub 2013 Aug 28.

Collision of extensive exocrine and neuroendocrine neoplasms in multiple endocrine neoplasia type 1 revealed by cytogenetic analysis of loss of heterozygosity: a case report.


・ALK/CEN2p Dual Color FISH Probe (GC041)

J Clin Pathol. 2013 Aug;66(8):705-7. doi: 10.1136/jclinpath-2012-201329. Epub 2013 Apr 25.

Aberrant anaplastic lymphoma kinase expression in high-grade pulmonary neuroendocrine carcinoma.


・ T/CEN6p Dual Color FISH Probe(GC079)

Journal of Neuropathology and Experimental Neurology, 72: 816-23, 2013

Molecular and Clinical Risk Factors for Recurrence of Skull Base Chordomas: Gain on Chromosome

2p, Expression of Brachyury, and Lack of Irradiation Negatively Correlate With Patient Prognosis.


・PIK3CA/CEN3q Dual Color FISH Probe(GC077)

Chin J Cancer Res. 2013 Aug;25(4):416-22. doi: 10.3978/j.issn.1000-9604.2013.08.03.

PIK3CA mutation in Chinese patients with lung squamous cell carcinoma.


・ MYB Split Dual Color FISH Probe(SP016)

Ophthalmology. 2013 May 29. pii: S0161-6420(13)00315-1. doi: 10.1016/j.ophtha.2013.03.030. [Epub ahead of print]

Adenoid Cystic Carcinoma of the Lacrimal Gland: MYB Gene Activation, Genomic Imbalances, and Clinical Characteristics.


・FGFR1/CEN8q Dual Color FISH Probe(GC55)

Oral Oncol. 2013 Jun;49(6):576-81. doi: 10.1016/j.oraloncology.2013.01.006. Epub 2013 Feb 19.

Frequency of Fibroblast Growth Factor Receptor 1 gene amplification in oral tongue squamous cell

carcinomas and associations with clinical features and patient outcome.


・ROS1 Split Dual Color FISH Probe(SP015)

Cancer. 2013 May 1;119(9):1627-35. doi: 10.1002/cncr.27967. Epub 2013 Feb 7.

Identification of ROS1 rearrangement in gastric adenocarcinoma.


・FGF3,FGF4/CEN11p Dual Color FISH Probe(GC63)

Hepatology. 2013 Apr;57(4):1407-15. doi: 10.1002/hep.25956. Epub 2013 Feb 11.

FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma.


・CHOP Split Dual Color FISH Probe(SP014)

Article first published online: 21 FEB 2013 DOI: 10.1111/his.12068

Dedifferentiated liposarcoma with homologous lipoblastic differentiation: expanding the spectrum to include low-grade tumours


・c-met/CEN7q Dual Color FISH Probe(GC004)

Oncotarget. 2013 Jan;4(1):9-17.

MET amplification as a potential therapeutic target in gastric cancer.


・ ROS1 Split Dual Color FISH Probe(SP015)

Ann Surg Oncol. 2012 Aug 23.

ROS1 Receptor Tyrosine Kinase, a Druggable Target, is Frequently Overexpressed in Non-Small Cell Lung Carcinomas Via Genetic and Epigenetic Mechanisms


・CALR/CEN19q Dual Color FISH Probe(GC033)

Am J Pathol. 2012 May;180(5):2076-83. doi: 10.1016/j.ajpath.2012.01.042. Epub 2012 Mar 17.

Aberrant calreticulin expression is involved in the dedifferentiation of dedifferentiated liposarcoma.


・ RET Split FISH Probe(V.2)(SP019), KIF5B/RET, SY FISH Probe(TR009)

Cancer Medicine, doi: 10.1002/cam4.13

RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer


・FGFR2/CEN10p Dual Color FISH Probe(GC018)

British Journal of Cancer 106, 727-732 (14 February 2012)

FGFR2 gene amplification and clinicopathological features in gastric cancer


・RET Split Dual Color FISH Probe(SP018)

Nat Med. 2012 Feb 12;18(3):375-7. doi: 10.1038/nm.2644.

KIF5B-RET fusions in lung adenocarcinoma.


・c-met/CEN7q Dual Color FISH Probe(GC004)

Lung Cancer. 2012 Jan;75(1):89-94. doi: 10.1016/j.lungcan.2011.06.004. Epub 2011 Jul 5.

Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma patients.


・NF2/CEN22q(GC003) ,1p36.33/CEN1p(GC030), CHGA-ITPK1/CEN14q(GC035) FISH Probe

J Clin Pathol. 2012 Jan;65(1):77-82. doi: 10.1136/jclinpath-2011-200208. Epub 2011 Nov 12.

Genomic gains and losses in malignant mesothelioma demonstrated by FISH analysis of paraffin-embedded tissues.


・TFE3 Split Dual Color FISH Probe(SP004)

Int J Clin Oncol. 2011 Oct;16(5):577-80. doi: 10.1007/s10147-010-0154-6. Epub 2010 Dec 15.

A case study of metastatic Xp11.2 translocation renal cell carcinoma effectively treated with sunitinib.


・SYT Split Dual Color FISH Probe(SP002), EWS Dual Color FISH Probe(SP003)

Am J Clin Pathol. 2010 Aug;134(2):323-31. 

Detection of SYT and EWS gene rearrangements by dual-color break-apart CISH in liquid-based cytology samples of synovial sarcoma and Ewing sarcoma/primitive neuroectodermal tumor.


・p53/CEN17q Dual Color FISH Probe(GC011)

Clin Cancer Res. 2011 Apr 1;17(7):1731-40. doi: 10.1158/1078-0432.CCR-10-1996. Epub 2011 Feb 15.

Copy-neutral loss of heterozygosity at the p53 locus in carcinogenesis of esophageal squamous cell carcinomas associated with p53 mutations.


・SYT Split Dual Color FISH Probe(SP002)

Hum Pathol. 2010 Jun 29  41:1394-404. 

Diagnostic utility of dual-color break-apart chromogenic in situ hybridization for the detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma.


・FFPE FISH Pretreatment kit2(K008)

Int J Cancer. 2009 Oct 15;125(8):1859-67. doi: 10.1002/ijc.24538.

Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression.


・EML4/ALK, DY Translocation Dual Color FISH Probe(TR001)

Clin Cancer Res. 2008 Oct 15;14(20):6618-24. doi: 10.1158/1078-0432.CCR-08-1018.

Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts.


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